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학술발표 섬, 무한한 가능성과의 만남

Anti-inflammatory effect of sulfated polysaccharide from Celluclast-assisted extract of Sargassum horneri *

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조회 132회 작성일 21-12-15 16:00
발표자 김서영, 이원우
년도 2021 년
구분(구두/포스터) 포스터
학술대회명 한국조류학회
초록 "Saragassum horneri is an edible brown alga that has recently been moved into the coasts of Jeju Island from China, which made huge economic and environmental loss. Thus, utilization of this biomass becomes a big issue with the local authorities. Therefore,we evaluated the anti-inflammatory potential of  crude  polysaccharides extracted  with  Celluclast  enzyme  from  S.  horneri  in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The pOlysaccharides from the Celluclast enzyme digest (CCP)  showed the highest inhibition of  NO production, and  dose-dependently down-regulated  the  protein expressions of  iNOS  and  COX-2  as well  as  the  production of inflammatory cytokines. In addition, CCP inhibited the activation of NF-kB p50 and p65 and phosphorylation of MAPKs. Furthermore, FT-IR analysis showed that the FT-IR spectrum of CCP is similar to that of commercial fucoidan. Our results suggest that CCP has anti-inflammatory activities and is a potential candidate for the formulation of a functional food ingredient to treat inflammatory diseases."

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